Investigations into genetic basis of Ayurvedic dosha classifications

Extracts from a recent study published in Nature magazine investigating this topic:

“Concept of Prakriti in Ayurveda and its relationship with genomics was hypothesized over a decade ago. Subsequent studies have attempted to correlate Prakriti classification with genetic information and association of single nucleotide polymorphisms (SNPs) in HLA-DRB1, CYP2C19, EGLN1, inflammatory and oxidative stress related genes, CD markers for various blood cells, DNA methylation alterations and risk factors of cardiovascular or inflammatory diseases have been reported. While these studies have shown the association of specific genes with the phenotype of a particular Prakriti, the association of genomic variations with Prakriti classification was lacking. This is the first attempt to classify the Prakritis using genome-wide SNP markers and to provide a scientific basis for Prakriti classification……..

We found that PGM1 correlates with phenotype of Pitta as described in the ancient text of Charaka Samhita, suggesting that the phenotypic classification of India’s traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine………..

In Ayurveda, characteristics of Pitta include digestion, metabolism and energy production. Interestingly, we found PGM1 gene is in the center of many metabolic pathways i.e. glycolysis or gluconeogenesis (hsa00010); pentose phosphate pathway (hsa00030); galactose metabolism (hsa00052); purine metabolism (hsa00230) and; starch and sucrose metabolism (hsa00500). Our finding suggests that the function of the gene directly correlates with the role of Pitta in metabolism as described in Ayurvedic literature………

In conclusion, our preliminary study suggests that the Prakriti classification, as a foundation for the practice of Ayurveda, has a genetic basis and does provide clues for further studies.”


Study: Genome-wide analysis correlates Ayurveda Prakriti by Periyasamy Govindraj and others.

Single nucleotide polymorphism explained


All content is for educational purposes only. Please consult your medical practitioner before attempting any therapeutic, nutritional, exercise or meditation related activity.

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